I-Berberine, noma iBerberine Hydrocloworide, iyingxenye etholakala ezitshalweni eziningi. Kungasiza ukwelapha imibandela efana nesifo sikashukela, i-cholesterol ephezulu kanye nomfutho wegazi ophakeme. Kodwa-ke, imiphumela emibi ingafaka isisulu esicasukile nesicanucanu.
I-Berberine ibiyingxenye yemithi yendabuko yesiShayina neyakwa-Ayurvedic izinkulungwane zeminyaka. Isebenza emzimbeni ngezindlela ezahlukahlukene futhi iyakwazi ukubangela ushintsho ngaphakathi kwamaseli omzimba.
Ucwaningo nge-Berberine luphakamisa ukuthi lungaphatha izifo ezahlukahlukene ze-metabolic, kufaka phakathi isifo sikashukela, ukukhuluphala kanye nesifo senhliziyo. Kungathuthukisa nempilo ye-gus.
Yize i-berberine ibonakala iphephile futhi inemiphumela emibi embalwa, kufanele uthintane nodokotela wakho ngaphambi kokuyithatha.
I-Berberene ingaba yi-ejenti ephumelelayo ye-antibacterial. Isifundo esingu-2022 sathola ukuthi iBerberine isiza ukuvimbela ukukhula kweStaphylococcus aureus.
Olunye ucwaningo luthole ukuthi i-berberine ingalimaza i-DNA namaprotheni ama-bacterium athile.
Ucwaningo lukhombisa ukuthi i-berberine inezindawo zokulwa nokuvuvukala, okusho ukuthi kungasiza ukuphatha isifo sikashukela nezinye izifo ezihambisana nokuvuvukala.
Ucwaningo lubonisa ukuthi i-berberine ingahle ibe yinzuzo ekwelapheni isifo sikashukela. Ucwaningo selukhombisile ukuthi lungaba nomthelela omuhle ku:
Ukuhlaziywa okufanayo kutholwe ukuthi inhlanganisela ye-berberine kanye nomuthi ophula ushukela wegazi wawusebenza kakhulu kunesidakamizwa sodwa.
Ngokusho kocwaningo luka-2014, i-berberine ikhombisa ukuthembisa njengokwelashwa okungenzeka kwesifo sikashukela, ikakhulukazi kubantu abangakwazi ukuthatha izidakamizwa ezikhona zangezekele ngenxa yesifo senhliziyo, ukwehluleka kwesibindi, noma izinkinga zezinso.
Okunye ukubukezwa kwezincwadi kutholakale ukuthi i-berberine ehlanganiswe nezinguquko zendlela yokuphila inciphise amazinga kashukela wegazi ancishisiwe ngaphezu kwezinguquko zendlela yokuphila eyedwa.
I-Berberine ibonakala isebenze i-amp-acted i-Protein Kinase, esiza ukulawula ukusetshenziswa komzimba koshukela wegazi. Abaphenyi bakholelwa ukuthi lokhu kusebenza kungasiza ukwelapha isifo sikashukela nezinkinga zempilo ezihlobene njengokukhuluphala kanye ne-cholesterol ephezulu.
Enye ukuhlaziywa kwe-meta okwenziwa ngo-2020 kubonise ukuthuthuka kwesisindo somzimba kanye namapharamitha we-metabolic ngaphandle kokunyuka okubalulekile emazingeni aphezulu we-enzyme.
Kodwa-ke, ososayensi badinga ukuqhuba izifundo ezinkulu, ezingaboni kabili ukuze zikwazi ukubona ngokugcwele ukuphepha nokusebenza kahle kwe-berberine.
Khuluma nodokotela wakho ngaphambi kokuthatha i-berberine yesifo sikashukela. Kungenzeka kungabi lula kuwo wonke umuntu futhi kungaxhumana neminye imithi.
Izinga eliphakeme le-cholesterol ne-triglycerin eliphansi le-lipoprotein (LDL) lingakhulisa ubungozi besifo senhliziyo nokushaywa unhlangothi.
Obunye ubufakazi bukhombisa ukuthi i-berberine ingasiza i-cholesterol ephansi ne-triglycerides. Ngokusho kokubuyekezwa okukodwa, izifundo zezilwane nezabantu zikhombisa ukuthi i-berberine yehlisa i-cholesterol.
Lokhu kungasiza ukwehlisa i-LDL, i-cholesterol "embi", futhi yandise i-HDL, i-cholesterol "enhle".
Ukubuyekezwa kwezincwadi kutholakale ukuthi i-berberine ehlanganiswe nezinguquko zendlela yokuphila isebenza ngempumelelo ekwelapheni i-cholesterol ephezulu kunendlela yokushintsha indlela yokuphila yedwa.
Abaphenyi bakholelwa ukuthi iBerberine ingahle yenza ngokufanayo nasezidakamizweni ze-cholesterol ngaphandle kokubangela imiphumela emibi efanayo.
Ukubuyekezwa kwezincwadi kutholakale ukuthi i-berberine yaphumelela kakhulu ngokuhambisana nezidakamizwa ezihlinza ngegazi kunasekuqaleni.
Ngaphezu kwalokho, imiphumela evela ezifundweni ze-rat iphakamisa ukuthi i-berberine ingabambezela ukuqala komfutho wegazi ophakeme futhi isize ukunciphisa ubulukhuni bayo lapho kwenzeka khona umfutho wegazi ophakeme.
Ukubuyekezwa okukodwa kubikwa ukuncipha kwesisindo okubalulekile kubantu abathatha ama-milligrams angama-750 (MG) we-barberry kabili nsuku zonke izinyanga ezi-3. I-Barberry yisitshalo esiqukethe i-berbeline eningi.
Ngokwengeziwe, isifundo esingaboni kabili sathola ukuthi abantu abane-metabolic syndrome abathathe u-200 mg we-barberry kathathu ngosuku abenenkomba ye-mistry yomzimba ephansi.
Iqembu elenza olunye ucwaningo luphawule ukuthi i-berberine ingasebenza kusebenze izicubu ze-adipose ezinsundu. Lesi sicubu sisiza umzimba ukuguqula ukudla ube ekushiseni komzimba, futhi ukwenziwa kabusha kokwenza kusebenze kungasiza ukuphatha ukukhuluphala kanye ne-metabolic syndrome.
Ezinye izifundo zibonisa ukuthi i-berberine isebenza ngokufanayo ne-metformin yezidakamizwa, odokotela abavame ukunquma ukwelapha uthango 2 Ushukela. Eqinisweni, i-berberine ingaba nekhono lokushintsha amagciwane esisusi, angasiza ukuphatha ukukhuluphala kanye nesifo sikashukela.
I-Polycystic Ovary Syndrome (PCOS) yenzeka lapho abesifazane benamazinga aphezulu ama-hormone athile wesilisa. I-Syndrome ingukungalingani kwe-hormonal kanye ne-metabolic okungaholela ekutheni inzalo kanye nezinye izinkinga zempilo.
I-Polycystic Ovary Syndrome ihlotshaniswa nezinkinga eziningi ze-berberine ezingasiza ukuxazulula. Isibonelo, abantu abane-PCOS kungenzeka futhi:
Odokotela kwesinye isikhathi banquma i-metformin, umuthi wesifo sikashukela, ukwelapha ama-PCOs. Njengoba i-berberine inemiphumela efanayo ku-metformin, kungahle kube nenketho yokwelashwa okuhle kwama-PCOs.
Ukubuyekezwa okuhleliwe kwathola i-berberine ukuze yethembisa ekwelapheni i-polycystic ovary syndrome nge-insulin ukumelana. Kodwa-ke, ababhali baphawula ukuthi ukuqinisekiswa kwale miphumela kudinga ucwaningo olwengeziwe.
I-Berberene ingadala izinguquko kuma-molekyuli amaselula, ezingaba nenye inzuzo engaba khona: ukulwa nomdlavuza.
Olunye ucwaningo lubonisa ukuthi i-berberine isiza ukwelapha umdlavuza ngokuvimbela ukuqhubeka kwayo kanye nomjikelezo wempilo ejwayelekile. Kungadlala nendima ekubulaleni amaseli womdlavuza.
Ngokusekelwe kule mininingwane, ababhali bathi i-Berberine "isebenza kahle, iphephile, futhi engabizi" izidakamizwa zeziphilayo.
Kodwa-ke, kubalulekile ukukhumbula ukuthi abacwaningi bafunda kuphela imiphumela ye-berberine kumaseli womdlavuza elabhorethri hhayi ebantwini.
Ngokusho kwezinye izifundo ezishicilelwe ngo-2020, uma ngabe iBerberine ingasiza ekwelapheni umdlavuza, ukuvuvukala, isifo sikashukela kanye nezinye izifo, kungahle kube khona ngemiphumela yayo ezuzisayo ku-microbiome emihle. Ososayensi bathole ukuxhumana phakathi kwe-gut microbiomet (amakoloni ama-bacteriya emathunjini) nalezi zimo.
I-Berberene inezakhiwo ze-antibacterial futhi ibonakale isusa ama-bacterium ayingozi kusuka ku-gut, ngaleyo ndlela athuthukise ukukhula kwamagciwane aphilile.
Ngenkathi izifundo kubantu nasegunjini zibonisa lokhu kungaba iqiniso, ososayensi bexwayisa ukuthi kudingeka ucwaningo oluningi ukuze kuqinisekiswe ukuthi iBerberine lithinta kanjani.
I-American Association of Naturopathic Odokotela (AANP) ithi izithasiselo ze-Berberine ziyatholakala ngesengezo noma ifomu le-capsule.
Bangeza ukuthi izifundo eziningi zincoma ukuthatha ama-900-1500 mg ngosuku, kepha abantu abaningi bathatha ama-500 mg kathathu ngosuku. Kodwa-ke, i-AANP inxusa abantu ukuthi babonane nodokotela ngaphambi kokuthatha i-berberine ukubheka ukuthi ngabe kuphephile yini ukuyisebenzisa futhi yini umthamo ongathathwa.
Uma udokotela evuma ukuthi iBerberine iphephile ukuyisebenzisa, abantu kufanele futhi bahlole ilebula yomkhiqizo yesitifiketi sabaphathi besithathu, njengeNational Science Foundation (NSF) noma i-NSF International, kusho i-AANF.
Ababhali beSifundo se-2018 bathola ukuthi okuqukethwe kwama-berbene ahlukene amaphilisi ahlukahlukene, okungaholela ekudidekeni ngokuphepha kanye nemithamo. Abatholanga ukuthi izindleko eziphakeme zibonisa ikhwalithi yomkhiqizo ephakeme.
I-US Food Food and Drug Administration (FDA) ayilawuli izithasiselo zokudla. Asikho isiqinisekiso sokuthi izithako ziphephile noma zisebenza, futhi akuhlangene ngaso sonke isikhathi ukuqinisekisa ikhwalithi yomkhiqizo.
Ososayensi bathi iBerberine neMetformin babelana ngezimpawu eziningi futhi zombili zingaba usizo ekwelapheni isifo sikashukela sohlobo 2.
Kodwa-ke, uma udokotela enquma i-metformin kumuntu, akufanele acabangele i-berbene njengenye indlela ngaphandle kokuxoxa ngayo nodokotela wazo.
Odokotela bazonikeza umthamo ofanele we-metformin kumuntu osuselwa ezifundweni zemitholampilo. Akunakwenzeka ukwazi ukuthi izithasiselo zifana kanjani nale mali.
I-Berberene ingahle ihlangane ne-metformin futhi ithinte ushukela wegazi lakho, okwenza kube nzima ukulawula. Kokunye ukuhlola, ukuthatha i-berberine kanye ne-metformin ndawonye kunciphise imiphumela ye-metformin ngo-25%.
I-Berberine kungenzeka ngelinye ilanga ibe yindlela efanelekile yokuthola i-metformin yokulawula ushukela wegazi, kepha kudingeka ucwaningo oluthe xaxa.
Isikhungo Sikazwelonke sempilo ehambisanayo nehlanganisiwe (NCCIH) sithi iGoldenerod, equkethe i-Berberine, akunakwenzeka ukuthi ibangele imiphumela emibi emibi esikhathini esifushane. Kodwa-ke, akukho mininingwane eyanele ukukhombisa ukuthi iphephile ekusetshenzisweni kwesikhathi eside.
Ezifundweni zezilwane, ososayensi baphawula imiphumela elandelayo ngokuya ngohlobo lwesilwane, inani kanye nesikhathi sokuphatha:
Kubalulekile ukukhuluma nodokotela wakho ngaphambi kokuthatha i-berberine noma ezinye izithasiselo njengoba kungenzeka zingaphephile futhi zingalungele wonke umuntu. Noma ngubani onokusabela komzimba kunoma yimuphi umkhiqizo wamakhambi kufanele ayeke ukuyisebenzisa ngokushesha.
Isikhathi sePosi: Dec-07-2023