I-Berberine, noma i-berberine hydrochloride, iyinhlanganisela etholakala ezitshalweni eziningi. Kungasiza ukwelapha izimo ezifana nesifo sikashukela, i-cholesterol ephezulu kanye nomfutho wegazi ophakeme. Nokho, imiphumela engemihle ingase ihlanganise ukucasuka kwesisu kanye nesicanucanu.
I-Berberine ibiyingxenye yomuthi wendabuko wamaShayina kanye ne-Ayurvedic izinkulungwane zeminyaka. Isebenza emzimbeni ngezindlela ezahlukene futhi iyakwazi ukudala izinguquko ngaphakathi kwamaseli omzimba.
Ucwaningo nge-berberine luphakamisa ukuthi ingaphatha izifo ezihlukahlukene ze-metabolic, kuhlanganise nesifo sikashukela, ukukhuluphala, nesifo senhliziyo. Kungase futhi kuthuthukise impilo yamathumbu.
Nakuba i-berberine ibonakala iphephile futhi inemiphumela emibi embalwa, kufanele uthintane nodokotela wakho ngaphambi kokuyithatha.
I-Berberine ingaba i-ejenti ye-antibacterial ephumelelayo. Ucwaningo lwango-2022 lwathola ukuthi i-berberine isiza ukuvimbela ukukhula kwe-Staphylococcus aureus.
Olunye ucwaningo lwathola ukuthi i-berberine ingalimaza i-DNA namaprotheni amanye amagciwane.
Ucwaningo lubonisa ukuthi i-berberine inezindawo zokulwa nokuvuvukala, okusho ukuthi ingasiza ekwelapheni isifo sikashukela nezinye izifo ezihambisana nokuvuvukala.
Ucwaningo lubonisa ukuthi i-berberine ingaba wusizo ekwelapheni isifo sikashukela. Ucwaningo lubonise ukuthi lungaba nomthelela omuhle kulokhu:
Ukuhlaziya okufanayo kutholwe ukuthi inhlanganisela ye-berberine nomuthi owehlisa ushukela egazini yayisebenza kangcono kunanoma yimuphi umuthi wodwa.
Ngokocwaningo lwango-2014, i-berberine ibonisa isithembiso njengendlela yokwelapha isifo sikashukela, ikakhulukazi kubantu abangakwazi ukuthatha izidakamizwa ezikhona ze-antidiabetic ngenxa yesifo senhliziyo, ukwehluleka kwesibindi, noma izinkinga zezinso.
Okunye ukubuyekezwa kwezincwadi kwathola ukuthi i-berberine ehlanganiswe nezinguquko zendlela yokuphila yanciphisa amazinga kashukela egazi ngaphezu kokushintsha kwendlela yokuphila yodwa.
I-Berberine ibonakala yenza i-AMP-activated protein kinase, esiza ukulawula ukusetshenziswa komzimba kashukela egazini. Abacwaningi bakholelwa ukuthi lokhu kusebenza kungasiza ekwelapheni isifo sikashukela kanye nezinkinga zempilo ezihlobene njengokukhuluphala kanye ne-cholesterol ephezulu.
Okunye ukuhlaziywa kwe-meta okwenziwa ngo-2020 kubonise ukuthuthuka kwesisindo somzimba kanye nemingcele ye-metabolic ngaphandle kokunyuka okuphawulekayo kumazinga we-enzyme yesibindi.
Kodwa-ke, ososayensi badinga ukwenza izifundo ezinkulu, ezingaboni kabili ukuze banqume ngokugcwele ukuphepha nokusebenza ngempumelelo kwe-berberine.
Khuluma nodokotela wakho ngaphambi kokuthatha i-berberine yesifo sikashukela. Ingase ingafaneli wonke umuntu futhi ingase ihlanganyele neminye imithi.
Amazinga aphezulu e-cholesterol kanye ne-low-density lipoprotein (LDL) triglycerides angandisa ingozi yesifo senhliziyo nesifo sohlangothi.
Obunye ubufakazi bubonisa ukuthi i-berberine ingasiza ukwehlisa i-cholesterol ye-LDL nama-triglycerides. Ngokusho kokubuyekezwa okunye, izifundo zezilwane nezabantu zibonisa ukuthi i-berberine yehlisa i-cholesterol.
Lokhu kungasiza ukwehlisa i-LDL, i-cholesterol “embi”, futhi kwandise i-HDL, i-cholesterol “enhle”.
Ukubuyekezwa kwezincwadi kwathola ukuthi i-berberine ehlanganiswe nezinguquko zendlela yokuphila iphumelela kakhulu ekwelapheni i-cholesterol ephezulu kunokushintsha indlela yokuphila yodwa.
Abacwaningi bakholelwa ukuthi i-berberine ingase isebenze ngendlela efanayo nezidakamizwa ezehlisa i-cholesterol ngaphandle kokubangela imiphumela emibi efanayo.
Ukubuyekezwa kwezincwadi kwathola ukuthi i-berberine yayisebenza kahle kakhulu ekuhlanganisweni nezidakamizwa zokwehlisa umfutho wegazi kunokuba iyodwa.
Ukwengeza, imiphumela evela ocwaningweni lwamagundane iphakamisa ukuthi i-berberine ingase ibambezele ukuqala komfutho wegazi ophakeme futhi isize ekunciphiseni ukuqina kwayo lapho umfutho wegazi ophezulu wenzeka.
Ukubuyekezwa okukodwa kubike ukulahlekelwa kwesisindo okuphawulekayo kubantu abathatha ama-milligrams angu-750 (mg) we-barberry kabili nsuku zonke izinyanga ezingu-3. I-Barberry isitshalo esiqukethe i-berberine eningi.
Ukwengeza, ucwaningo oluyimpumputhe kabili lwathola ukuthi abantu abane-metabolic syndrome abathatha ama-200 mg we-barberry kathathu ngosuku babenenkomba yesisindo somzimba ephansi.
Ithimba elenza olunye ucwaningo liphawule ukuthi i-berberine ingase yenze kusebenze izicubu ze-adipose ensundu. Lesi sicubu sisiza umzimba ukuguqula ukudla kube ukushisa komzimba, futhi ukwenza kusebenze okwengeziwe kungasiza ekwelapheni ukukhuluphala kanye nesifo se-metabolic.
Olunye ucwaningo lubonisa ukuthi i-berberine isebenza ngendlela efanayo nesidakamizwa i-metformin, odokotela abavame ukusinikeza ukwelapha isifo sikashukela sohlobo 2. Eqinisweni, i-berberine ingaba nekhono lokushintsha amagciwane amathumbu, angasiza ekwelapheni ukukhuluphala kanye nesifo sikashukela.
I-Polycystic ovary syndrome (PCOS) yenzeka lapho abesifazane benezinga eliphezulu lamahomoni athile wesilisa. I-syndrome ukungalingani kwe-hormonal kanye ne-metabolic okungaholela ekungazali kanye nezinye izinkinga zempilo.
I-Polycystic ovary syndrome ihlotshaniswa nezinkinga eziningi i-berberine engasiza ukuzixazulula. Isibonelo, abantu abane-PCOS bangase babe:
Kwesinye isikhathi odokotela banikeza i-metformin, umuthi wesifo sikashukela, ukwelapha i-PCOS. Njengoba i-berberine inemiphumela efanayo ku-metformin, ingase futhi ibe inketho yokwelapha enhle ye-PCOS.
Ukubuyekezwa okuhlelekile kwathola ukuthi i-berberine iyathembisa ekwelapheni i-polycystic ovary syndrome ngokumelana ne-insulin. Kodwa-ke, ababhali bayaqaphela ukuthi ukuqinisekiswa kwale miphumela kudinga ucwaningo olwengeziwe.
I-Berberine ingase ibangele izinguquko kuma-molecule eselula, angase abe nenye inzuzo engaba khona: ukulwa nomdlavuza.
Olunye ucwaningo luphakamisa ukuthi i-berberine isiza ukwelapha umdlavuza ngokuvimbela ukuqhubeka kwawo kanye nomjikelezo wokuphila ojwayelekile. Kungase futhi kubambe iqhaza ekubulaleni amangqamuzana omdlavuza.
Ngokusekelwe kule datha, ababhali bathi i-berberine iyisidakamizwa “esisebenza kahle kakhulu, esiphephile, futhi esithengekayo” sokulwa nomdlavuza.
Nokho, kubalulekile ukukhumbula ukuthi abacwaningi bafunde kuphela imiphumela ye-berberine kumaseli omdlavuza elabhorethri hhayi kubantu.
Ngokocwaningo olwanyatheliswa ngo-2020, uma i-berberine ingasiza ekwelapheni umdlavuza, ukuvuvukala, isifo sikashukela nezinye izifo, kungase kube ngenxa yemiphumela yayo enenzuzo ku-gut microbiome. Ososayensi bathole ukuxhumana phakathi kwe-gut microbiome (amakoloni amagciwane emathunjini) kanye nalezi zimo.
I-Berberine inezindawo zokulwa namagciwane futhi ibonakala isusa amagciwane ayingozi emathunjini, ngaleyo ndlela ikhuthaze ukukhula kwamagciwane anempilo.
Nakuba ucwaningo kubantu namagundane luphakamisa ukuthi lokhu kungaba yiqiniso, ososayensi baxwayisa ngokuthi ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe ukuthi i-berberine ibathinta kanjani abantu nokuthi iphephile yini ukuyisebenzisa.
I-American Association of Naturopathic Physicians (AANP) ithi izithasiselo ze-berberine zitholakala kufomu le-supplement noma le-capsule.
Bangeza ukuthi izifundo eziningi zincoma ukuthatha i-900-1500 mg ngosuku, kodwa abantu abaningi bathatha i-500 mg kathathu ngosuku. Kodwa-ke, i-AANP inxusa abantu ukuthi babonane nodokotela ngaphambi kokuthatha i-berberine ukuze bahlole ukuthi iphephile yini ukuyisebenzisa nokuthi ingaphuzwa ngamuphi umthamo.
Uma udokotela evuma ukuthi i-berberine iphephile ukuthi isetshenziswe, abantu kufanele bahlole ilebula yomkhiqizo ukuthola isitifiketi esivela eceleni, njenge-National Science Foundation (NSF) noma i-NSF International, kusho i-AANP.
Ababhali bocwaningo lwango-2018 bathola ukuthi okuqukethwe kwama-capsules e-berberine ahlukene kuyehluka kakhulu, okungaholela ekudidekeni mayelana nokuphepha kanye nomthamo. Abazange bathole ukuthi izindleko eziphakeme zazibonisa ikhwalithi yomkhiqizo ephakeme.
I-US Food and Drug Administration (FDA) ayizilawuli izithasiselo zokudla. Asikho isiqinisekiso sokuthi izithasiselo ziphephile noma ziyasebenza, futhi akwenzeki njalo ukuqinisekisa ikhwalithi yomkhiqizo.
Ososayensi bathi i-berberine ne-metformin zabelana ngezici eziningi futhi zombili zingase zibe usizo ekwelapheni isifo sikashukela sohlobo 2.
Kodwa-ke, uma udokotela enika umuntu i-metformin, akufanele acabangele i-berberine njengenye indlela ngaphandle kokuxoxa ngayo nodokotela wakhe kuqala.
Odokotela bazonikeza umthamo olungile we-metformin kumuntu ngokusekelwe ezifundweni zomtholampilo. Akunakwenzeka ukwazi ukuthi izithasiselo zihambisana kahle kangakanani nale mali.
I-Berberine ingase ihlanganyele ne-metformin futhi ithinte ushukela wakho wegazi, okwenza kube nzima ukulawula. Ocwaningweni olulodwa, ukuthatha i-berberine ne-metformin ndawonye kwehlisa imiphumela ye-metformin ngama-25%.
I-Berberine ngolunye usuku ingase ibe enye indlela efanelekile ye-metformin yokulawula ushukela wegazi, kodwa ucwaningo olwengeziwe luyadingeka.
I-National Center for Complementary and Integrative Health (NCCIH) ithi i-goldenrod, equkethe i-berberine, akunakwenzeka ukuthi ibangele imiphumela emibi kakhulu esikhathini esifushane uma abantu abadala beyithatha ngomlomo. Nokho, alukho ulwazi olwanele lokubonisa ukuthi iphephile ukusetshenziswa isikhathi eside.
Ezifundweni zezilwane, ososayensi baphawule le miphumela elandelayo kuye ngohlobo lwesilwane, inani kanye nesikhathi sokuphatha:
Kubalulekile ukukhuluma nodokotela wakho ngaphambi kokuthatha i-berberine noma ezinye izithasiselo njengoba zingase zingaphephile futhi zingafanele wonke umuntu. Noma ubani ongezwani nanoma yimuphi umkhiqizo we-herbal kufanele ayeke ukuwusebenzisa ngokushesha.
Isikhathi sokuthumela: Dec-07-2023