I-Berberine: Ukusetshenziswa, izinzuzo, izithasiselo kanye nemiphumela emibi

I-Berberene inomlando omude wokusebenzisa ezinhlelweni zemithi yendabuko, njengeI-Ayurvedanomuthi wase-East Asia. Kuyindlela yokunambitha ebabayo enamakhemikhali ethathwe ezitshalweni ezahlukahlukene, njenge-hydrastis canadensis (Goldtis Chinensis (Coptis Chinensis (COPTIS noma i-Gollenthread) kanye neBerberis Vulimis (barberry). Ucwaningo lubonisa ukuthi i-berberine ingaba nempahla enolwazi lokulwa namagciwane, kanye nomthelela omuhle ku-metabolism, kepha okunye ukubhekana nokulingwa kwemitholampilo kuyadingeka ukuqinisekisa lezi zinzuzo.

I-Berberene nayo ingaba nezinzuzo eziningi zomzimba nemisebenzi yemithi esigabeni, izinso, inhliziyo kanye nobuchopho, ngokuxhasa ukwesekwa kwe-metabolic. Isibonelo, i-berberine isebenze i-expyme amp-isebenze i-amp-ack-amp-ack-amp-amp-act i-kinase yamaprotheni, okubonisa ukuthi ucwaningo lusiza ukulawula i-metabolism, ukusebenza kwamaseli namazinga wamandla.

I-Berberene isetshenziselwa ikakhulukazi ukusizaushukela wegazi ophansi, thuthukisa impilo yenhliziyo, ukunciphisa ukucindezela okuxinative futhiI-cholesterol engezansi, futhi nangezinhlaka zalo zokulwa nodonga, ezilwa nokuvuvukala kanye nomdlavuza, kusho uHeather Zwickey, Ph.d, uProfesa we-Immunology emhlanganweni wezemvelo ePortland, e-Oregon.

I-Berberene itholakala ngokujwayelekile kwifomu le-capsule, kepha futhi yakhiwa njengamaconsi eso namagceke ezinhlobonhlobo zezimo zokuvuvukala zesikhumba, amehlo noma amalunga.

Izitshalo eziningi namakhambi aqukethe i-berbesine asetshenziswe ngomuthi izinkulungwane zeminyaka, kepha kudingeka ngokwengeziwe ukucwaninga ukuze aqonde izindlela ze-compound zezenzo nemiphumela yesikhathi eside. Ngalokho kusho ukuthi, ucwaningo lubonisa kungazuzisa impilo yomuntu ngezindlela eziningi.

Kungasiza ukwehlisa ushukela wegazi futhi kuvikele ukumelana ne-insulin

Ukubuyekezwa okungu-2022 kuAma-moleculeIbonisa i-berberine ingasizaAmazinga we-glucose ephansiNgoba kwandisa ukukhiqizwa kwe-insulin futhi kuthuthukise ukuzwela kwe-insulin, yize kudingeka ucwaningo oluthe xaxa ukuze uqonde ngokugcwele le miphumela[1].

Kungasiza ukwehlisa i-cholesterol

Ucwaningo lukhombisa i-berberine ingaba nomphumela omuhleI-Cholesterol ye-LDLFuthi i-cholesterol ephelele, noma kudingeka izivivinyo ezengeziwe zemitholampilo ukuze ziqonde ngokuphelele lesi simangalo sezempilo.

Ingathuthukisa impilo ye-cardiovascular

I-Berberene ingaba nomthelela omuhle ezicubu zenhliziyo, ikakhulukazi ezimweni ze-Ischemia (ukunikezwa kwegazi okunganele), ngokuthuthuka kwemisipha yenhliziyo, ukwehlisa ukuvuvukala, ukwehlisa ingcindezi yegazi kanye nokwenyuka komthelela wegazi.

Ingahle ibe nemiphumela yokulwa nokuvuvukala

I-Berberine i-ALKALOID ebabayo enikeza imiphumela ehlakaniphile elwa nokuvuvukala, kusho u-Alicia McCubbins, udokotela we-naturopathic osuselwa eVancouver, eWashington. Lezi zakhiwo zingasizakala zizonke izinqubo ze-metabolic, njengokufaka isandla ekuvinjelweni kwe-atherossteosis, thayipha isifo sikashukela, ukukhuluphala kanye nezinkinga zenhliziyo. Izakhiwo zikaBerberene zokulwa nokuvuvukala zifunde ubude, kepha inqubo yayo yokusebenza ayikaqondakali, igqamisa isidingo socwaningo olwengeziwe.

Ingahle ibe nezakhiwo ze-antioxidant

Ukubuyekezwa kuka-2018 ngaphakathiImingcele ekhemisiIphetha ukuthi imiphumela ye-antioxidant's Antioxidant ifaniswa neyevithamini C, i-antioxidant enamandla amakhulu[2]. Izinto ezifana neVitamin C neBerberene Act njenge-antioxidants ukusiza ukugwema umonakalo wamahhala wokulimala kungadala amaseli.

Ingaba nezakhiwo ze-antibacterial ne-antimicrobial

"I-Berberine inezakhiwo ze-astringent futhi ibhekwa njenge-antimicrobial yemvelo enamathuba ama-aout bacteria, ama-parasites kanye nesikhunta / uCandida," usheshe uDkt McCubbins. Lezi zakhiwo ze-antimicrobial zingasiza ukuthuthukisa imibandela ethile, enjenge-acuteuhudo, Dysentery, i-jaundice kanye nezifo zangasese sowesifazane, yize kudingeka ucwaningo oluthe xaxa ukusekela lezi zimangalo. Uma umuntu ekholelwa ukuthi zinokutheleleka ngegciwane lanoma yiluphi uhlobo, kufanele babhekane nomhlinzeki wazo wezokunakekelwa kwempilo ukuze azoxilongwa kanye nokwelashwa ngaphambi kokuthatha i-berberine noma enye into engeza.

Ingathuthukisa impilo yokugaya

I-Berberene ingahlomula ukukhathazeka kokugaya, njengokuqunjelwa futhiumukle, ngokusho kukaDkt McCubbins. "Lawa ma-alkaloid anganikeza izinzuzo ezithembisayo kuxhumano lobuchopho lwe-gut-brain," uyanezela, egcizelela ukubaluleka kokuxhumanisa phakathi kokugaya, imizwa nempilo yonke.

Ingasekela ukunciphisa umzimba kanye nokuphathwa kwesisindo

I-Berberene ingasiza ekunciphiseni isitoreji samafutha ne-glucose ngokwenza ngcono izinqubo ze-metabolic, njengokuqhekeka kwama-lipid (amafutha) noshukela, ucwaningo lubonisa. Umthelela omuhle weBerbesherlines on the gut microbiome ungaba nengxenye esemqoka ekusekelweni kwayo kokuphathwa kwesisindo.

Ingahle ithuthukise izimpawu ze-polycystic ovarian syndrome (PCOS) kanye ne-ovulation

Ngokusho kokubuyekezwa kuAma-molecule, ukuthatha ama-milligrams ayi-1,500 eBerbeline ngosuku izinyanga ezintathu ancishiselwe amazinga aphezulu we-testosterone kwabesifazane abanayoI-PCOS[3]. Lesi simo singafaka amazinga we-hormone angajwayelekile futhi siphumela ebangeni elingama-ukungalingani, okuholela ezindabeni ezinjengama-cysts amancane kuma-ovari noma ukuya esikhathini okungajwayelekile. Ochwepheshe nabo bakholelwa ukuthi iBerberine ithuthukisa ukumelana ne-insulin, okuyisici esijwayelekile se-PCOs. Kodwa-ke, abacwaningi baphakamisa ukuthi izivivinyo ezengeziwe zomtholampilo ziyadingeka ukuqinisekisa lo mphumela we-berberine, kufaka phakathi ubude bokwelashwa kanye ne-yokwelapha.

 

Ungayithatha kanjani i-berbeline?

Izithasiselo ze-Berberine zitholakala kwi-capsule, ithebhulethi noma i-tincture, zivumela ukulungiswa okuqondile nokusetshenziswa okulula. Ama-caplule angahle akhetheke ukuthi iningi labathengi linikezwe ukunambitheka okubabayo kakhulu, lichaza uDkt McCubbins. "I-Berberine ivame ukuthathwa njengendawo yokugaya ama-tonic to 5 kuya ku-30 ​​ngaphambi kokudla. UBerberene ngokwemvelo unyuse okuvusa amajusi esiqhingi ekugayweni okusebenzayo okusebenzayo, "uyaqhubeka.

Umthamo we-Berberine

Abantu kufanele babhekane nomhlinzeki wezokunakekelwa kwempilo noma i-herbalist yokuxoxa nge-dosing enembile (engalinganiswa), futhi afunde imiyalo yomenzi, kusho uDkt Zwickey. "Ngokuvamile kubhekwa njengephephile emithanjeni [yansuku zonke] ye- [Nokho] ye- [Nokho Ngaphezu kwama-2 amagremu. Ukuze [uzuze imiphumela efanele], kungenzeka ukuthi umuntu ofuna ukusebenzisa okungenani i-1 gram (ama-milligram ayi-1000) ngosuku. Izithasiselo eziningi [ziqukethe ama-milligram angama-500 nge-capsule ngayinye, ngakho-ke othile angafuna ukuthatha [okungenani ezimbili] caplules ngosuku, "uyaqhubeka.

Umthamo weBerberine kungenzeka ancike kwizinhloso zempilo yomuntu ngamunye. Mayelana noshukela wegazi, ukubuyekezwa okuhlelekile ngo-2019 kanye nokuhlaziywa kwe-meta kuI-Endocrine Journalkutholwe ukuthatha ngaphansi kwama-2 amagremu e-berbeline ngosuku izinyanga ezintathu athinte kahle amagluco amazinga e-glucose wababambiqhaza ngoshukela ongu-2[4].

Okwamanje, isibuyekezo socwaningo olutholakalayo kuIzindlela zokwelapha ezihambisanayo ekusebenzeni kwemitholampilokuhlolisise impendulo yethamo ye-berberine ekhipha abantu abanokukhuluphala futhi bafuna ukuphathwa kwesisindo, ukuthola ukuthi imithamo yama-milligram angama-500 athathwe kathathu ngosuku okuholele ekunciphiseniI-Body Mass Index (BMI), ukujikeleza okhalweni nesisindo somzimba[5].

Imiphumela emibi yeBerberine

Izithasiselo ze-Berberene zingaba nemiphumela emibi, kufaka phakathi uhudo, isisu sicasulwa futhi sithi uDkt McCubbins.

U-Berberene uyavuka ekudumeni nasekuthandeni kakhulu emphakathini wehlise isisindo, "uyaqhubeka. "Qaphela futhi uthintane nodokotela we-naturopathic mayelana nokusetshenziswa kokwelapha [kwe-Berberine ngaphambi kokuqeda]."

Ngenkathi i-berberine imvamisa ibekezelelwa kahle, ingadala ubuhlungu besisu nokudabuka, ukuqunjelwa, isifo sohudo, ukuthopha, isicanucanu nokuhlanza, kunezela uDkt Zwickey.

Ngabe i-berberine iphephile?

Ukukhathazeka okuyinhloko kokuphepha kwe-berberine ukuthi kungaxhumana nemithi eminingana, kusho uDkt Zwickey. Ukuxhumana okunzima kakhulu okungenzeka kungokwe-cyclosporine, umuthi we-immunosupprespive osetshenziswa ngemuva kokufakelwa kwezitho futhi usize ukuphatha izimo ze-autoimmune ezifanaI-Rheumatoid arthritis, njengoba i-berberine inyusa ukugcwala kwe-cyclosporine egazini, uyachaza.

Akunandaba ukuthi umuntu uthatha i-berberine njenge-standalone ekhishwe isengezo noma ngefomethi ye-herbl yonke, kubalulekile ukulandela imiyalo yethamo enconyiwe enikezwe ngumenzi womkhiqizo noma ochwepheshe bezempilo. I-Berberene ihlanganiswe nezingane, kanye nokukhulelwa kanye nokuthambisa abantu, amanothi uDkt Zwickey.

Yini okufanele uyicabangele lapho uthenga i-berberine?

Ngoba abakhiqizi abaningi bahlanza i-berberine kusuka esitshalweni, ekuhlolweni kwelebhu yesithathu ye-berberine, amandla, ikhwalithi kanye nobumsulwa kubalulekile, kusho uDkt Zwickey. "Umuntu kufanele abe ncamashi kakhulu mayelana nesengezo kwiNkampani yesengezo seGradence - ukuqinisekisa ukuhlolisisa okwenzeka emthethweni ezinkampanini ezihlonishwayo kanye nokuqinisekiswa kwekhwalithi [inezela uDkt McCubbins.

Kubalulekile futhi ukuqinisekisa ukuthi i-berberine itholwe ngokuzinzile, ngokusho kukaDkt McCubbins. "IGoldNen, yize ingumthombo omuhle kakhulu weBersene, isengozini. Uyachaza: Amalebula amaningi okufaka acacisa kusuka kulokho amakhambi akhishwe yi-berbere.

Njengoba i-berberine iswele izifundo zokuphepha zesikhathi eside, umuntu kufanele abonane nomhlinzeki wezokunakekelwa kwempilo ngaphambi kokungeza i-berberine kwirejista yazo kabusha ukuze aqinisekise ukuthi kufanelekile futhi iphephile ngezidingo zabo zempilo ezihlukile. Ukuze ufunde kabanzi ngezinzuzo zezempilo zeBerberine, khuluma nodokotela we-naturopathic, umvikeli oqinisekisiwe noma i-acupuncturist.