I-Berberine: Ukusetshenziswa, Izinzuzo, Izithasiselo kanye Nemiphumela Eseceleni

I-Berberine inomlando omude wokusetshenziswa ezinhlelweni zemithi yendabuko, njengeI-Ayurvedakanye nemithi yaseMpumalanga Asia.Kuyinhlanganisela yamakhemikhali enambithekayo ebabayo etholakala ezitshalweni ezihlukahlukene, njenge-hydrastis canadensis (i-goldenseal), i-coptis chinensis (i-coptis noma i-goldenthread) ne-berberis vulgaris (i-barberry).Ucwaningo luphakamisa ukuthi i-berberine ingase ibe nezindawo zokulwa namagciwane kanye nama-antibiotic, kanye nomthelela omuhle kumetabolism, kodwa ezinye izivivinyo zomtholampilo ziyadingeka ukuze kuqinisekiswe lezi zinzuzo.

I-Berberine ingase futhi ibe nezinzuzo eziningi zomzimba nemisebenzi yezemithi esibindini, ezinso, enhliziyweni nasengqondweni, engase inikeze ukwesekwa okwengeziwe kwe-metabolic.Isibonelo, i-berberine yenza kusebenze i-enzyme ye-AMP-activated protein kinase, ucwaningo oluphakamisa ukuthi isiza ukulawula umzimba, ukusebenza kwamaseli kanye namazinga wamandla.

I-Berberine isetshenziselwa kakhulu ukusiza okungenzekaushukela wegazi ophansi, ukuthuthukisa impilo yenhliziyo, ukunciphisa ukucindezeleka okwenziwe nge-oxidative futhii-cholesterol ephansi, kanye nemiphumela yaso yokulwa nesifo sohudo, ukulwa nokuvuvukala kanye nokulwa nomdlavuza, kusho uHeather Zwickey, Ph.D, uprofesa we-immunology e-National University of Natural Medicine e-Portland, e-Oregon.

I-Berberine ivame ukutholakala efomini le-capsule, kodwa futhi yenziwe njengamaconsi esweni namajeli ezimweni ezihlukahlukene zokuvuvukala kwesikhumba, amehlo noma amalunga.

Izitshalo eziningi namakhambi aqukethe i-berberine sekusetshenziswe izinkulungwane zeminyaka njengomuthi, nokho ucwaningo olwengeziwe luyadingeka ukuze kuqondwe izindlela zokusebenza zenhlanganisela kanye nemiphumela yesikhathi eside.Ngalokho, ucwaningo lubonisa ukuthi kungase kuzuze impilo yomuntu ngezindlela eziningi.

Ingasiza Ukwehlisa Ushukela Wegazi futhi Ivimbele Ukumelana Ne-insulin

Isibuyekezo sango-2022 kuAma-moleculeikhombisa ukuthi i-berberine ingasizaamazinga eglucose aphansingoba kwandisa ukukhiqizwa kwe-insulin futhi kuthuthukisa ukuzwela kwe-insulin, nakuba ucwaningo olwengeziwe luyadingeka ukuze uqonde ngokugcwele le miphumela[1].

Ingasiza Ukwehlisa I-Cholesterol

Ucwaningo lubonisa ukuthi i-berberine ingaba nomthelela omuhleI-cholesterol ye-LDLkanye ne-cholesterol ephelele, nakuba ukuhlolwa okwengeziwe kwemitholampilo kuyadingeka ukuze kuqondwe lesi simangalo sezempilo ngokuphelele.

Kwangathi Ingathuthukisa Impilo Yenhliziyo

I-Berberine ingase ibe nomthelela omuhle ezicutshini zenhliziyo, ikakhulukazi ezimweni ze-ischemia (ukungatholakali kwegazi okwanele), ngokuthuthukisa amandla emisipha yenhliziyo, ukunciphisa ukuvuvukala, ukunciphisa ukucindezeleka okwenziwe nge-oxidative, ukwehlisa umfutho wegazi nokwandisa ukuphuma kwenhliziyo.

Ingase Ibe Nemiphumela Eqeda Ukuvuvukala

I-Berberine iyi-alkaloid ebabayo enikeza imiphumela yesistimu yokulwa nokuvuvukala, kusho u-Alicia McCubbins, udokotela we-naturopathic ozinze eVancouver, eWashington.Lezi zakhiwo zingase zizuzise izinqubo ze-metabolic jikelele, ezifana nokuba nomthelela ekuvimbeleni i-atherosclerosis, uhlobo lwesifo sikashukela sohlobo 2, ukukhuluphala kanye nezinkinga zenhliziyo.Izakhiwo zikaBerberine zokulwa nokuvuvukala ziye zacutshungulwa isikhathi eside, kodwa indlela yokusebenza kwayo ayikaqondwa, okugqamisa isidingo socwaningo olwengeziwe.

Ingase Ibe Nezakhiwo Ze-Antioxidant

Isibuyekezo sango-2018 kuImingcele ku-Pharmacologyiphetha ngokuthi imiphumela ye-berberine yokulwa ne-antioxidant iqhathaniswa nekavithamini C, i-antioxidant enamandla kakhulu[2].Izinto ezifana novithamini C kanye ne-berberine zisebenza njengama-antioxidants ukusiza ukugwema ukulimala okungabangelwa ama-radicals mahhala kumaseli.

Ingase Ibe Nezinto Ezilwa Namagciwane Nezibulala Amagciwane

"I-Berberine ine-astringent properties futhi ithathwa njenge-antimicrobial yemvelo enamandla okuxosha amagciwane, ama-parasites kanye nesikhunta/candida," kusho uDkt. McCubbins.Lezi zici ze-antimicrobial zingasiza ekuthuthukiseni izimo ezithile, ezifana nezibiisifo sohudo, isifo sohudo, i-jaundice kanye nezifo zesitho sangasese sowesifazane, nakuba ucwaningo olwengeziwe ludingeka ukusekela lezi zimangalo.Uma umuntu ekholelwa ukuthi unokutheleleka ngebhaktheriya kwanoma yiluphi uhlobo, kufanele abonane nomhlinzeki wakhe wezempilo ukuze axilongwe kahle futhi alashwe ngaphambi kokuphuza i-berberine nanoma yisiphi esinye isithasiselo.

Ingase Ithuthukise Impilo Yokugaya Ukudla

I-Berberine ingase izuze ukukhathazeka kokugaya ukudla, njengokuqunjelwa kanyeisilungulela, ngokusho kukaDkt. McCubbins."Lawa ma-alkaloid angase anikeze izinzuzo ezithembisayo ekuxhumaneni kwe-gut-brain," uyanezela, egcizelela ukubaluleka kokuxhumana phakathi kokugaya, isimo sengqondo kanye nempilo yonke.

Ingase Isekele Ukunciphisa Isisindo Nokulawulwa Kwesisindo

I-Berberine ingasiza ekunciphiseni ukugcinwa kwamafutha kanye ne-glucose ngokwenza ngcono izinqubo ze-metabolic, njengokuwohloka kwe-lipids (amafutha) noshukela, ucwaningo luphakamisa.Umthelela omuhle we-Berberines ku-gut microbiome ungase ube yingxenye ebalulekile ekusekeleni kwayo ukulawula isisindo.

Ingase Zithuthukise Izimpawu Ze-Polycystic Ovarian Syndrome (PCOS) kanye Nokuvuthwa Kweqanda

Ngokusho kokubuyekezwa kuAma-molecule, ukuthatha i-1,500 milligrams ye-berberine ngosuku izinyanga ezintathu kunciphisa amazinga e-testosterone aphezulu kwabesifazane abaneI-PCOS[3].Lesi simo singase sihlanganise amazinga amahomoni okuzala angavamile futhi siphumele ezinhlobonhlobo zokungalingani, okuholela ezinkingeni ezifana namaqhubu amancane kuma-ovari noma ukuya esikhathini okungavamile.Ochwepheshe bakholelwa ukuthi i-berberine ithuthukisa ukumelana ne-insulin, okuyisici esivamile se-PCOS.Kodwa-ke, abacwaningi basikisela ukuthi ezinye izivivinyo zomtholampilo ziyadingeka ukuze kuqinisekiswe lo mphumela we-berberine, okuhlanganisa ubude bokwelashwa kanye ne-dosing yokwelapha.

 

Ungayithatha kanjani i-Berberine?

Izithako ze-Berberine zitholakala nge-capsule, ithebhulethi noma ifomu le-tincture, okuvumela ukudoswa okunembayo nokusetshenziswa kalula.Amaphilisi angase athandeke kubathengi abaningi uma kubhekwa ukunambitheka kwawo okubabayo, kuchaza uDkt. McCubbins.“I-Berberine ivame ukuthathwa njenge-tonic yokugaya ukudla emizuzwini emi-5 kuye kwengama-30 ngaphambi kokudla.I-Berberine iyababa ngokwemvelo evuselela ijusi yesisu ukuze igaye ukudla okusebenzayo,” kuqhuba yena.

I-Berberine Dosage

Abantu ngabanye kufanele bathintane nomhlinzeki wezempilo noma udokotela wamakhambi ukuze baxoxe ngokuphuza umthamo onembile (okungalingani), futhi bafunde imiyalelo yomkhiqizi, kusho uDkt. Zwickey.“Ngokuvamile kubhekwa njengokuphephile kumithamo [yansuku zonke] [engekho ngaphezu] kwamagremu angu-2.Ukuze [ukuzuza imiphumela emihle], umuntu cishe ufuna ukusebenzisa okungenani igremu elingu-1 (ama-milligram angu-1000) ngosuku.Izithasiselo eziningi [ziqukethe] ama-milligrams angu-500 ikhephuseli ngalinye, ngakho-ke othile angafuna ukuphuza amaphilisi [okungenani amabili] ngosuku,” kuqhubeka yena.

Umthamo we-Berberine ungancika ezinhlosweni zezempilo zomuntu.Mayelana noshukela wegazi, ukubuyekezwa okuhlelekile kuka-2019 kanye nokuhlaziywa kwe-meta ku-I-Endocrine Journalokutholwe ukuthatha ngaphansi kwamagremu ama-2 e-berberine ngosuku izinyanga ezintathu kuthinte kahle amazinga eglucose wegazi kubahlanganyeli abanesifo sikashukela sohlobo 2[4].

Ngaleso sikhathi, isibuyekezo socwaningo olutholakalayo kuImithi Yokwelapha Ehambisanayo Emsebenzini Womtholampiloihlole impendulo yomthamo we-berberine extract kubantu abakhuluphele futhi abafuna ukuphathwa kwesisindo, yathola ukuthi imithamo yama-milligrams angu-500 ethathwe kathathu ngosuku iholele ekwehleniInkomba yesisindo somzimba (BMI), ukuzungeza ukhalo nesisindo somzimba[5].

I-Berberine Side Effects

Izithako ze-Berberine zingaba nemiphumela ethile engemihle, kuhlanganise nesifo sohudo, ukucasuka kwesisu kanye nekhanda elibuhlungu, kusho uDkt. McCubbins.

"I-Berberine ikhula ngokuthandwa futhi idayiswa kakhulu emphakathini wokunciphisa umzimba," uyaqhubeka."Qaphela futhi uthintane nodokotela we-naturopathic mayelana [nokusetshenziswa] kokwelapha [kwe-berberine ngaphambi kokuyidla]."

Nakuba i-berberine ivame ukubekezelelwa kahle, ingase ibangele ubuhlungu besisu kanye nokuphazamiseka, ukuqunjelwa, isifo sohudo, ukuphefumula, isicanucanu nokuhlanza, kunezela uDkt. Zwickey.

Ingabe i-Berberine Iphephile?

Ukukhathazeka okuyinhloko kokuphepha kwe-berberine ukuthi ingase ihlangane nemithi eminingana, kusho uDkt. Zwickey.Ukusebenzisana okunamandla kakhulu okungase kube khona i-cyclosporine, umuthi ovimbela ukuzivikela komzimba osetshenziswa ngemuva kokufakelwa isitho somzimba nokusiza ukuphatha izimo ze-autoimmune ezifanaisifo samathambo, njengoba i-berberine inyusa ukugcwala kwe-cyclosporine egazini, uyachaza.

Kungakhathaliseki ukuthi umuntu uthatha i-berberine njengesithasiselo esikhishwe ezimele noma ngayo yonke ifomethi ye-herbl, kubalulekile ukulandela imiyalelo yethamo enconyiwe ehlinzekwa umkhiqizi womkhiqizo noma uchwepheshe wokunakekelwa kwezempilo.I-Berberine ivinjelwe izingane, kanye nabantu abakhulelwe nabancelisayo, kuphawula uDkt. Zwickey.

Yini Okufanele Uyicabangele Lapho Uthenga I-Berberine?

Ngenxa yokuthi abakhiqizi abaningi bahlanza i-berberine esitshalweni, ukuhlolwa kwelabhorethri yenkampani yangaphandle ukuze kuhlonzwe i-berberine, amandla, ikhwalithi nokuhlanzeka kubalulekile, kusho uDkt. Zwickey."Umuntu kufanele acacise kakhulu mayelana nokuthola usizo oluvela enkampanini yezengezo yezinga likadokotela ukuze aqinisekise ukuhlolwa okuvela eceleni okuvela ezinkampanini ezihlonishwayo kanye nokuqinisekiswa kwekhwalithi [yemithetho] engcono kakhulu [yomthamo]," kunezela uDkt. McCubbins.

Kubalulekile futhi ukuqinisekisa ukuthi i-berberine itholakala ngendlela efanele, ngokusho kukaDkt. McCubbins.“I-Goldenseal, nakuba ingumthombo omuhle kakhulu we-berberine, isengozini.Izinkampani ezengeza ezihloniphekile ziyalwazi lolu [daba],” echaza.Amalebula amaningi e-supplement acacisa ukuthi yimaphi amakhambi akhishwa i-berberine.

Njengoba i-berberine ishoda ngezifundo zokuphepha zesikhathi eside, umuntu kufanele abonane nomhlinzeki wezempilo ngaphambi kokwengeza i-berberine ohlelweni lwabo lokwengeza ukuze aqinisekise ukuthi ifanelekile futhi iphephile ezidingweni zabo zezempilo ezihlukile.Ukuze ufunde kabanzi mayelana nezinzuzo zezempilo ezingaba khona ze-berberine, khuluma nodokotela we-naturopathic, i-herbalist eqinisekisiwe noma i-acupuncturist.